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Tomasello G, Petrelli F, Ghidini M, Russo A, Passalacqua R, Barni S

For caffeine loaded liposome (CF-L), same method was performed, but we add 10 ml CF stock solution (in PBS or in H 2 O) as a hydration solution instead of PBS, or water to be loaded into the liposomes aqueous center

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By reducing IGFBP binding to negligible levels while preserving IGF1R affinity, LR3 enables sustained IGF1R activation in cell culture and in vivo models with practical dosing protocols