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Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on January 6th, 2026

Importantly, there are numerous studies showing, through the regulation of the aforementioned transcription factors and more, that 4-HNE causes cell cycle arrest and inhibits the proliferation of malignant cells through the p53 and p21 dependent pathways (for review see ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)

Human trials are sparse, small, and not yet replicated

Jethanandani, A

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