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A cofactor is a mineral, vitamin, or nutrient that is needed in order for an enzyme to work properly

sTFR was also found to be significantly and positively correlated with parameters of inflammatory activity and autoimmune disease ( Iron, as a regulator of the immune response, affects the phagocytosis of monocytes and macrophages

In BMAL1-knockout mice, pericytes progressively detach, extracellular matrix deposition is reduced, and tight junctions disassemble, leading to unstable neovasculature and loss of BBB integrity (79)

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