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The function of ECM includes maintaining mechanical tension of the matrix and facilitating cell communication through cell membrane surface receptor integrins (124)

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[297] found Amuc_2109 (-N-acetylhexosaminidase from Akk ) improved DSS-induced colitis as evidenced by lowered DAI, reduced weight loss, and increased colon length

Therefore, topical NSAIDs may have advantages over oral NSAIDs in some cases (e.g., osteoarthritis)