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therefore, DNA methylation at a single CpG site in an experimental sample is a quantitative trait, being a proportion of DNA strands that is methylated ( GENOME DISTRIBUTION OF DNA METHYLATION The CpG dinucleotides make up only about 1% of the human genome, which is less than one-fourth of the expected proportion if they were to be randomly distributed

The vaccine is highly effective and provides decades of protection (CDC hepatitis B)

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Shi L, Yang Y, Li M, Li C, Zhou Z, Tang G, et al

Instead, it's mostly absorbed in the back of the throat