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167 Epigenetic mechanisms, including DNA methylation and histone modification, contribute to chondrocyte senescence and are exacerbated by mechanical and oxidative stress

Hn ch ru bia, thuc l, cht kch thch: Nhng yu t ny c th lm suy gim lng Glutathione t nhin trong c th, nh hng n hiu qu s dng

GTP cyclic hydrolase 1 (GCH1) synthesizes tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2), of which BH4 has been shown to act as a direct radical-trapping antioxidant and to participate in ubiquinone synthesis to inhibit ferroptosis [46, 47]

Surprisingly, compared with the CM from the vector adipocytes, CM from the CPT2KD adipocytes remarkably upregulated the mRNA expression of pro-inflammatory macrophage markers in BMDMs, whereas CM from the SIRT3OE-CPT2KD adipocytes partially reversed these changes (Fig

Applied in experimental research setups focused on growth-related pathways