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Taken together, current evidence indicates that T cells in RA patients exhibit a distinct metabolic signature characterized by dysregulated glycolysis and impaired mitochondrial function

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Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide