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Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone

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While direct studies of their combined use are limited, their individual mechanisms suggest potential synergy in tissue repair, angiogenesis, and anti-inflammatory regulation