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Another nonclassical degradation inducer of the GPX4 protein is a missense mutation in the gene encoding its synthase and its pathogenic variant (the R152H variant), suggesting that Lys125/Lys127 are sites for ubiquitin ligation and subsequent degradation [69,70]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Gao L, Kim KJ, et al

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