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and de novo synthesis of GSH by cancer cells occurs as follows: GSH is first exported from the cell of origin via transporters known as Multiresistance Drug Proteins (MRPs), which belongs to the ATP binding cassette (ABC)s transporter family and is well-known player in cancer resistance mechanisms (33)

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ACTL6A knockdown (KD) via short hairpin RNA (shRNA) transfection exerted a marked negative effect on GC cell proliferation, while overexpression of ACTL6A exerted a positive effect on GC cell proliferation (Fig

10.1371/journal.pone.0008579 PLoS One 139 YuX.CuiL.ZhangZ.ZhaoQ.LiS