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After stopping supplementation, some people may notice decreased energy levels, especially if their supplement regimen provided strong antioxidant support

The ability to acquire choline and amino acids from the diet and to salvage the purine nucleotides makes the role of 5,10-methylene-THF, in dTMP synthesis, one of the most significant metabolic functions for dietary folate

CYP2C8, CYP2C18, and CYP2C19 are also involved [72,73,74,75]

In either event, most of these patients state that these types of medications dont necessarily help them to feel better, more rested, or alert