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Bayesian data assimilation has been suggested as a method to integrate patient data and address uncertainty in individualized treatments, a strategy that may also be applicable to peptide-based therapeutics

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Impaired mitophagy not only hampers mitochondrial quality control (54, 55), but also may trigger the release of pro-inflammatory factors and pro-apoptotic signals from dysfunctional mitochondria (56), thereby worsening cellular stress and potentially contributing to pathological changes, such as muscle atrophy (57)