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In this complex interrelation between the neuroendocrine and the immuneinflammatory processes, the presence of a transdiagnostic convergence across somatic and mental disorders of impaired inflammatory activity reinforces the significance of the scientific knowledge regarding comorbidity (79, 80) as an essential field of research with a holistic perspective

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TUE guidance documents including new regulations on glucocorticoids In order to assist physicians and athletes, in the last few weeks, WADA published the following guidance documents on managing TUEs to include the new regulations on glucocorticoids: General document on glucocorticoids and TUEs Checklists for athletes and treating physicians on a number of medical conditions for which glucocorticoids may be used TUE Physician Guidelines for TUE Committees on how to evaluate TUE requests for glucocorticoids for different medical conditions Educational resources In addition to the guidance documents listed above, WADA has provided a number of educational resources as part of its Code Implementation Support Program (CISP), which can be accessed on the Agencys Anti-Doping Education and Learning Platform (ADEL)

It binds to GHRH receptors on somatotroph cells in the anterior pituitary and stimulates endogenous growth hormone secretion