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A meta-analysis of global birth prevalence of spina bifida showed that when a national, mandatory program to fortify the diet with folate was compared to countries without such a fortification program, there was a 30% reduction in live births with spina bifida

Their work specifically identifies Muribaculaceae as a key microbial mediator in curcumins anxiolytic effects via the microbiota-gut-brain (MGB) axis (Zhang et al., 2022)

Here is what the clinical data actually shows when you line up the results side by side

Hcy appears to play a vital role (see Figure 7 ) and its elevation in some MTHFR variants suggests increased risk

From there, the vitamin B12 is transported into your bloodstream