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Bidirectional mediation analysis revealed that smoking modulated gut microbes via gene expression, with key metabolites like porphobilinogen and bilirubin linked to microbial changes

Tobacco use has been linked to tooth decay, as the tar in cigarettes can cause staining of the enamel which makes it more susceptible to cavities

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[1] Smoking is primarily practiced as a route of administration for psychoactive chemicals because the active substances within the burnt, dried plant leaves (or other chemical) can vaporize into a gaseous state and be delivered into the respiratory tract, where they are rapidly absorbed into the bloodstream through the lungs and can reach the central nervous system

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