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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]

NAC limits the hepatoxicity of APAP by increasing the synthesis of GSH in the liver [39]

These steps culminated in 2002 with an important DoD acquisition management text on increased and open competition that specifically referenced the enhanced use of SBIR by ACAT program managers

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells

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