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Future therapeutic strategies for COPD should focus on disrupting key pathogenic circuits of small airway disease

At the same time, the proportion of never smokers increased from 44.8% (95% CI: 39.850.0%) in 1997 to 63.5% (95% CI: 56.671.4%) in 2025, and is projected to rise further to 70.6% (95% CI: 61.182.3%) by 2040, representing around 7.4 million people who have never smoked

It causes atherosclerosis (vascular calcification) and narrowing of the heart (coronary) arteries which ultimately leads to heart attacks and sudden cardiac death