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Other synaptic signalling molecules positively associated with cognitive fitness in AD include neuritin-1 (NRN1) 11,12,13,16 and brain-derived neurotrophic factor (BDNF) 17,18 , whereas proteins associated with cognitive frailty include gut-derived cholecystokinin (CCK) and the chromogranins A/B (CHGA/B) 11,19

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