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Converting to intrinsic solubility separates the effect of ionization state from the experimental measurements and focuses the task on the fundamental solubility of the compound

If neurological symptoms are present (such as paraesthesia, ataxia, cognitive changes, or visual disturbances), more intensive treatment is required

H3K9ac, which promotes transcriptional activation, declines by 58%, contributing to chromatin compaction and impaired gene expression (93)

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