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Despite the antitumor effect of erastin, evidence has also shown that iron concentration and macrophage polarization in the tumor microenvironment promote the resistance of ovarian cancer cells to erastin-induced ferroptosis

Moreover, as pointed by there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later (Vaja et al.)

This is meaningful early-phase data, but it falls far short of the Phase III trial evidence that would be required for FDA approval

The ketamine infusion was administered intravenously over 40 min, while participants were lying supine in the MRI scanner