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Human ferroportin mediates proton-coupled active transport of iron

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In contrast, other cases of bioactivation may lead to the production of harmful metabolites that result in toxicity or side effects

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Oxidative modification or carbonylation covalently modifies endogenous enzymes and proteins, which can result in the loss of protein function, insulin resistance (IR), and impaired cell function, and play a significant role in the etiology of several human diseases (2, 5, 6, 15, 37, 46, 47)