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Its function is intricately related by its oligomeric state: the tetrameric form localizes to the cytoplasm and exhibits high pyruvate kinase activity, channeling glycolytic flux, whereas the dimeric form translocates to the nucleus upon TCR activation, where it functions as a protein kinase and transcriptional coactivator ( 3.1.3 mTOR/AMPK/HIF-1 axis: an integrated metabolic checkpoint The mTORAMPKHIF-1 axis serves as a central signaling hub that integrates nutrient availability, energy status, and immune signals to direct T cell differentiation (78)

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The results (Figure 7B) showed that approximately 5% of RGD-GHK and 0.5% of GHK were detected in the receptor cell, and 5% of RGD-GHK and 2.7% of GHK were detected in the skin