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These studies show that immune cell responses are less affected by cMRTP aerosols than cigarette smoke, especially regarding their release of chemokines and cytokines such as IL-8 and TNF [76, 77]

Smoking with them doesn't produce smoke so you can use them indoors

Of particular concern is DNA damage due to formaldehyde in the upper airways, as this damage could potentially contribute to the risk of nasopharyngeal and lung cancers specifically 3,4

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But its filtration of particles in the 0.3- to 1.0-micron range including smoke particles drops from 50% or greater to between 20% and 34%