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The inclusion-delivery interval tended to be longer in the NAC-treated severe IPTB cases, compared with severe cases who received placebo ((58 [16

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To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets

(Ohno S, Nakajin S, Drug MetabDispos, 37: 32-40, 2009), though mRNA and protein expression are not always well correlated, especially when comparing isoforms