These hallmarks of aging satisfy three conditions: (i) they become apparent with advancing age, (ii) experimentally perturbing them causes poor aging (iii) therapeutically intervening upon them prevents, delays or reverses aging phenotypes
However, at present, we should exercise caution in assuming that MOPr desensitization accounts completely for tolerance in vivo , as other mechanisms including altered activity in neuronal pathways or changes in gene expression could also be involved (Williams et al ., 2001)
Rodrigo JP, Hernandez-Prera JC, Randolph GW, Zafereo ME , Hartl DM, Silver CE, Surez C, Owen RP, Bradford CR, Mkitie AA, Shaha AR, Bishop JA, Rinaldo A, Ferlito A
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