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Overexpression of PGC-1 in human epithelial ovarian cancer (OC) cell line Ho-8910 induces apoptosis through the coordinated regulation of Bcl-2 and Bax expression, However, this effect is partially hindered by the PPAR antagonist GW9662 and suppression of PPAR

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Consequently, choline and betaine methylated the promoter region of PPAR-, suppressing mRNA expression and possibly the lipogenic actions of the encoded protein

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Overall, the development of PA-coupled siRNAs provides a promising approach to enhance the efficacy and stability of siRNA-based therapies, opening up new possibilities for targeted treatment options in various diseases, including cancer