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2019;92(12):e1322e1330

The larger individual is receiving roughly half the weight-adjusted dose

- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

A 2021 review confirmed no clinical trials targeting NNMT had been reported [5], and MOTS-c likewise has no large human efficacy trial proving it works as a fat-loss therapy

The body already runs on peptides, using these short amino-acid chains to direct repair, metabolism, and other functions