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Fatigue is one of the first signs of B12 deficiency

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 10mg/ml | 3.0ml | 1.0mg | | 15mg/ml | 2.0ml | 1.5mg | | 6mg/ml | 5.0ml | 0.6mg | **Best for:** Patients on 4-12mg weekly doses who want the best cost-per-milligram value

As systemic metabolic function improves, secondary benefits such as enhanced muscle definition, improved skin tone, and overall physical refinement may be observed, reflecting improved cellular energy balance and reduced inflammatory burden

Wallace, Natasha (2013-08-02)

pregnant women often receive IV thiamine if needed (e.g., for hyperemesis) without issue