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Under UV exposure, ATRA reduces the expression of proteins like E3 ligase Hrd1, sustaining Nrf2 activity and contributing to photoprotection and repair mechanisms essential for melanocytes

PMID: 9879640 | doi:10.1080/004982598238976 Hansen TK et al

This provides an objective biomarker of dysfunction even when structural imaging is normal [3]

Your digestive system can only absorb about 500mg of vitamin C at a time, with much of it lost before reaching your cells

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