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Numerous compounds have been used to inhibit the activity of endogenous mammalian G6PDH in vitro and/or in vivo such as the naturally occurring adrenal steroid dehydroepiandrosterone (DHEA) 3 , catechin gallates, especially epigallocatechin gallate (EGCG) 4 , chelerythrine (initially a PKC inhibitor) and PP2 (Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), primarily a Src kinase family inhibitor 5

albicans may also benefit from this mechanism, it possesses a family of secreted aspartyl proteinases capable of degrading albumin 28,29,30

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Instead, ABHD11 inhibition and impaired OGDHc function alter fatty acid metabolism and CD8 + T cell differentiation, increasing the central memory T cell (T CM ) pool