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The dysregulation of oxidative stress and inflammatory responses represents a hallmark of numerous pathological conditions, including sepsis, acute pancreatitis, asthma, joint inflammation, cardiovascular diseases (CVDs), and neurological disorders

Additionally, a competition for iron between the two entities exits, as iron is vital for both and is also implicated in macrophage defensive oxidative mechanisms and modulation of their phenotype

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Acting so, at micromolar concentrations, physiological ascorbate, a fully reduced form of vitamin C (VC), can reduce harmful ROS

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