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Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]

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406,407 Detailed analysis of astrocytic morphology using genetic reports (either ALDH1L1-eGFP reporter mice or viral transfection with astrocyte-targeted mCherry) revealed significant decrease of astrocytic complexity and shrinkage of astrocytic territorial domains in prefrontal cortex (Fig