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Jap J Pharmacol 19(3):418426 Takenoya F, Kageyama H, Hirako S, Ota E, Ogawa T, Wada N et al (2012) Neuropeptide w

Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42