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Persistent hyperglycemia leads to increased oxidative and ER stress, inflammation, and dysregulated autophagy, resulting in significant damage to retinal tissue [281]

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Another candidate, glial cell linederived neurotrophic factor (GDNF), has shown mixed results in early trials and faces similar delivery issues [114, 299]

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No study has linked them to tumor promotion, but if you have an active cancer, the theoretical risk of feeding blood vessels to it is worth taking seriously

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Specific fragments of the hormone are studied to understand individual domain activity

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45 The increase lasts for about two hours

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