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Members of the TLR family transmit signals to the tumor promoter, NF-B, to activate inflammatory cytokines and enzymes such as cyclooxygenase (COX-2, EC 1.14.99.1) [46], which promotes the proliferation, apoptotic resistance, and metastasis of tumor cells [47]

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Chem Rev 115(6):22742295 Shilatifard A (2006) Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression