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Some studies, particularly in animal models, suggest that iron overload enhances the proliferation of ectopic endometrial cells, contributing to lesion growth [24]

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As we age the cellular NAD + levels decline in part due to the reduced expression of one of the enzymes of NAD + salvage, nicotinamide phosphoribosyl transferase (NAMPT) as well as due to increased NAD + degradation via increased activity of the NAD + and NADP + hydrolyzing enzyme, CD38