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Once in the portal circulation, the copper complexes to albumin or amino acids with only a small fraction remaining free. A copper transporter (hCTR) for albumin-bound copper then transports the copper into the hepatocyte.12,13 There it interacts with several proteins that direct the copper to chaperones for incorporation into essential proteins (such as ceruloplasmin, copper/zinc superoxide dismutase, and cytochrome c oxidase), or into lysosomes for biliary excretion