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An important tool to assess the pathophysiological relevance of a mode of cell death or a specific mechanism such as LPO is to use a positive control, e.g., APAP + Fe 2+ or APAP in vitamin E-deficient mice

Meanwhile, we measured the levels of lipid peroxidation, a key indicator of ferroptosis, and found that RSL3 treatment completely disrupted the protective effect of uridine (Supplementary Fig

This allows the molecule to move through the stomach quickly and reach the absorption sites in the small intestine without being interfered with by food or heavy digestive activity

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