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Arch Endocrinol Metab (2017) 61(6):6007

The lyophilization process preserves structural stability and allows researchers to reconstitute the compound for controlled in vitro experimentation

This is primarily relevant for HSC70 (Roperto, 2022), although BAG3 has also been shown to associate with HSPA1A, increasing its activity (Xia et al., 2025) or together with HSP70, as shown by Ruggiero and colleagues reporting the first known inhibitor targeting both BAG3HSP70 (Ruggiero et al., 2025)

Initial tinnitus and acute hearing loss study results have already been published: One study showed the use of pine bark extract for an average of five weeks can reduce the symptoms of tinnitus by improving blood circulation in the inner ear

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