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Although the underlying mechanisms remain poorly understood, these observations emphasize the pivotal role of the kidney-brain axis in neurocognitive dysfunction

By avoiding the digestive tract altogether, these critical elements are quickly absorbed by cell membranesyielding more pronounced and longer-lasting results than traditional methods of supplementation

In addition, sterol regulatory element-binding proteins (SREBPs), such as SREBP-1, in diabetic kidneys aggravated DN by increasing lipid synthesis [237]

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