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NIMH genetics initiative

MAM is a consultant for Boehringer-Ingelheim, SoseiHeptares, and Neurocrine and sits on the advisory board for Quolet

Compared with the cecal metabolome of untreated mice, the levels of primary bile acids (especially taurocholic acid (TCA)), carbohydrates, and sugar alcohols were elevated, while the levels of bacterial metabolites (secondary bile acids and carboxylic acids) were decreased (Gutierrez et al., 2020)

Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet

Subsequently, a Phase IIa study was conducted in 2013 (ClinicalTrials.gov ID: NCT01926444) involving 240 patients