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These three compounds also exhibited more potent or comparable inhibitory activities to that of 1 toward cathepsins L and K, demonstrating that these act as pan-cathepsin inhibitors rather than selective inhibitors (Supplementary Fig

Aug 1 2019;3(8):1545-1573

The dose-dependent activation of the FAK-paxillin pathway has been documented in multiple studies

It was approved by the FDA in 2002 for the treatment of postmenopausal women and men with osteoporosis who are at high risk of fracture

Regular follow-up appointments allow the team to track progress, adjust dosages if needed, and address any concerns that arise along the way