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Nicotine is a parasympathomimetic substance that is found in cultivated tobacco plants (Nicotiana tabacum) and is as addictive as cocaine and other illegal substances

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The Federal Status of Marijuana and the Expanding Policy Gap with States , Congressional Research Service, March 6, 2023, IF12270, Although state laws do not affect the status of marijuana under federal law

They found marked alterations in the microbiome of smokers, as well as microbial metabolite changes that were similar to those found in the mouse smokers, including increased levels of DMG and its intermediate products