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Recent research suggests that Maillard reaction products affect APCs (in particular macrophages and DCs) and disrupt T cell responses under exposure to an allergen
Of particular note, the researchers reported that lower levels of CD320 or dietary B 12 restriction worsened the disease course in an animal model of MS and reduced the therapeutic efficacy of fingolimod, which occurred through a mechanism in which fingolimod hitchhikes by binding to the TCN2-B12 complex, allowing delivery of all to the astrocytes via interactions with CD320, with component losses disrupting the process and worsening disease
Neither peptide is FDA-approved, and there is no registered trial of the combination
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