According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
Precauciones : Aunque generalmente es seguro, pueden ocurrir efectos secundarios menores, incluyendo trastornos digestivos o reacciones alrgicas
Rapamycins Modulation of Metabolism Rapamycin was initially discovered as an antifungal metabolite from the bacteria Streptomyces hygroscopicus found in soil on Easter Island
Int J Mol Sci 22(18):9996 Mansoor S, Baloch FS, Chung YS (2024) In: Martnez AR (ed) Melatonin: a ubiquitous pleiotropic molecule
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