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This safety profile makes it suitable for individuals who cannot tolerate or are contraindicated for growth hormone therapy

intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies

Patients with a severe needle phobia, tremors, poor eyesight, or cognitive impairment should have a partner, family member, or healthcare provider administer the injection instead

This complete absence of tolerability-driven discontinuations indicates that even when side effects occurred, they were sufficiently mild that participants chose to continue treatment