Mitochondria is a cellular organelle often referred to the "powerhouse" of the cell, regulating a range of functions from energy generation, metabolism and cell survival
[6] In rats administered a 100 mg/kg bodyweight dose of kavain, over 90% was eliminated within 72 hours through urine and feces, either as unchanged compound or as metabolites
This free radical-mediated damage is considered as the initial pathogenic event in degeneration of melanocyte in generalized vitiligo and supplementing glutathione, which is a potent antioxidant, in vitiligo patients may prove to have therapeutic effect
There are two types of T cell responses, namely T helper (Th) cell type 1 associated with cellular immunity (production of interleukin IL-12, IL-2, IFN-) and Th cell type 2 related to humoral immunity (production of IL-4, IL-5, IL-6, IL-13, and antibodies)
Likewise, the overexpression of SOD is children with Down syndrome leads to a reduction of GSH and an increase in oxidative stress [13]