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N = 25 for each treatment group

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It enforces maladaptive metabolic reprogramming, corrupts mitochondrial signaling metabolites to promote exhaustion and inflammation, and disrupts dynamic balance and quality control systems, leading to the accumulation of damaged organelles

doi: 10.1016/j.brainres.2009.09.084 155 RamaswamyS.McBrideJ

Our data thus far show that 5FU drives increased mitochondrial biogenesis to address a functional requirement for increased mitochondrial ETC metabolism