Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A
10.1039/D3FO02330C 39
Among these compounds, the expression levels of glutathione persulfide, which exhibits strong antioxidant effects, were remarkably increased
Beyond repurposing existing drugs, Nrf2 activators (e.g., Dimethyl Fumarate) are particularly promising as they upstreamly regulate a network of antioxidant genes, including SLC7A11, GPX4, HO-1, and FTH1, thus simultaneously bolstering defenses against multiple drivers of ferroptosis ( Table 2 ) (176)
Over the last 30 years the number of diagnosed cases has increased from 0.4-0.5 to 4.0 per 1000 for autistic disorder and from 2 to 7.7-9.9 per 1000 for autism spectrum disorders [13] which is largely attributable to broadening diagnostic criteria, younger age at diagnosis and improved case ascertainment [4]