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For example, IRE delivers high-voltage electric pulses to disrupt cellular membrane integrity, inducing immunogenic cell death (ICD) through damage-associated molecular pattern (DAMP) release and loss of intracellular homeostasis ( + T-cell infiltration ( + T-cell quality/quantity and extend survival ( + T-cell conversion to antitumor Th1/Th17 subsets in MHC-I-low PDAC, where subsequent PD-L1 blockade activates compensatory cDC2-CD4 + T-cell axes ( 3.2 Hepatocellular carcinoma Clinical studies have established IRE as a safe and effective hepatocellular carcinoma (HCC) ablation modality, with ongoing optimization of efficacy assessment methods and device engineering complementing robust evidence of its antitumor effects

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Sep 2013;100(3):681-5

Why it was included in the FDA ban Melanotan II was banned for reported adverse effects like melanoma skin cancers, posterior reversible encephalopathy syndrome (a seizure and headache disorder), sympathomimetic toxidrome (symptoms of poisoning), and priapism (dangerous, prolonged erections)